The Amarillo Museum of Art has one of the largest collections of early American Modernist paintings, photography by Russell Lee, and textiles from the Middle East. Six galleries go along with 16 exhibitions per year in the intricate building designed by hailed architect Edward Durell Stone. For visitors looking for an educational experience, the museum offers tours, gallery lectures, films and publications. The museum has started a summer school for kids focused on developing creative abilities through painting, drawing, sculpting, mixed media and other mediums.

American Quarter Horse Hall of Fame & Museum is dedicated to the quarter horse, a breed smaller than average that can run short distances faster than any other horse. The AQHA offers memberships for those interested in owning their own quarter horse or entering it in competitions. Equestrian classes, seminars and training courses are available at the AQHA. Popular events such as racing and horse sales are held regularly.

Residing on a 15-acre plot of forest land, the Amarillo Zoo allows guests to experience over 45 different species of animals, along with rare plant breeds. The zoo is constantly adding new animals, some of the most popular being the Bengal Tigers and Wallabies. The Amarillo Zoo is the perfect place for a fun family outing while on vacation. Admission to the zoo is free, although the zoo accepts (and depends on) donations.

The Amarillo Botanical Gardens is a great place to visit for families or individuals who want to have a fun, educational experience involving the outdoors and native plant life. New exhibits are regularly being added, such as the Palo Duro Canyon Garden which should be open in the fall. Guided tours are available by request if made a week in advance.  Be sure to find the tropical conservatory for a chance to investigate rare and exotic indoor plants.

Constructed in 1914 by wealthy cattlemen, the Harrington House is a registered historical site of Amarillo, Texas. The house was built in a neoclassic style and the original structures are almost completely intact. The house was purchased in 1940 by the Harringtons, who traveled extensively and brought back rare artifacts and art to the house. Today, the house is open to the public for tours and guided lectures. Appointments must be made a week in advance.

An official listing on the National Register of Historic Places, the Natatorium, or as locals call it, "The Nat", used to be an indoor swimming pool in the 20s. In later years, the Nat was transformed into a dance hall. The Nat was a major venue for bands traveling through Route 66, with such legendary musicians as Duke Ellington and Louis Armstrong gracing the stage. Today, the Nat is as popular as ever, although it re-opened to the public as a large antique mall.

Traversing through the heart of the Palo Duro Canyon, trained cowboys guide visitors on horseback along dusty old trails during the Old West Stables tours. Three different tours are available for different types of guests; from a light, child-friendly half hour ride to a five hour ride for experienced riders through some of the canyon's most scenic regions.

The Texas Panhandle War Memorial pays tribute to soldiers who either lost their life or went missing in action since the Spanish American War. Several large red granite stones, each dedicated to a different war, lists the names of veterans who came from the 26 counties of the Texas Panhandle.

The historic Llano Cemetery was created by a group of dedicated volunteering women in 1901 and continues to be preserved as a notable heritage site in Amarillo. Picturesque Statues from the turn of the 20th Century can still be found on the property.

Constructed by Architect E.A. Harrison in 1930, the Santa Fe Building is one of the oldest structures in Amarillo. The architectural style it was built in is late Gothic revival. The building was originally headquarters for the Atchison, Topeka Santa Fe Railway Company, an extremely successful builder of new railroad lines throughout the country. Today, the building houses offices and is a registered historical site of Amarillo.